The woeful Red Devils conceded four home first-half goals in the Premier League for the first time having taken a second-minute lead through Bruno Fernandes' penalty.
Tanguy Ndombele levelled before Kane brilliantly set up Son to put Tottenham ahead before the favour was returned shortly after Anthony Martial was sent off, the Frenchman retaliating by striking Erik Lamela in the face after he appeared to be caught by a straw arm himself.