High profile NSW police detective Gary Jubelin resigns during misconduct investigations

Gary Jubelin, who led some of New South Wales' biggest criminal investigations, is resigning from the police force after he was removed from the William Tyrrell case.

Detective Chief Inspector Gary Jubelin has led many high profile cases. Source: AAP

One of NSW police's highest-profile detectives is resigning after he was stood down from the William Tyrrell disappearance case.

Detective Chief Inspector Gary Jubelin, who commanded dozens of officers on Strikeforce Roseann for four years, was taken off the Tyrrell case in March while he was investigated over allegations of misconduct.

Mr Jubelin had investigated other major crimes, including the murder of Mathew Leveson and the Bowraville case in his 34-year career.

NSW Detective Chief Inspector Gary Jubelin has resigned. Source: AAP

A report from the internal misconduct investigation is yet to be made public.

Police Minister David Elliott said he had no concerns about the William Tyrrell investigation.

"I have the absolute confidence of the NSW Police Force to do a thorough investigation into any matter," he told reporters on Sunday.

NSW Premier Gladys Berejiklian thanked Mr Jubelin for his contribution.

An inquest into the disappearance of William will continue in August.

William Tyrell went missing in 2014. Source: AAP/NSW POLICE

In one of the state's biggest mysteries, the three-year-old disappeared from foster grandmother's home at Kendall on the mid north coast on September 11 in 2014.

The inquest has been told the police investigation into William's disappearance was ongoing, with many officers still working hard to solve the mystery.