NSW's defence of the State of Origin shield have been thrown into disarray after possibly losing three halves options in a horror 24 hours.
A day before announcing their game-one team, Luke Keary was ruled out of contention due to concussion, before Adam Reynolds suffered a leg injury.
A third option, former halfback Mitchell Pearce, is also believed to have aggravated a groin issue that will limit his preparation if picked.
The triple blow means coach Brad Fittler may have to stick with out-of-form incumbents James Maloney and Nathan Cleary in Brisbane.
Blues adviser Greg Alexander all but confirmed Keary would have been picked if fit, however his chances were doomed after his second head knock of the year.
"Luke was looking like he was going to break into the team but I don't think Luke will take part. He won't be fit for game one," Alexander told ABC radio on Saturday.
Keary's scratching may have forced Fittler to opt for the club combination from the Rabbitohs, before Reynolds limped off in the first half of Saturday night's clash with the Wests Tigers.
The Rabbitohs No.7 was attempting a tackle on fullback Corey Thompson when his leg got caught under teammate Mark Nicholls.
It is understood Reynolds has been booked in for x-rays on Sunday morning, with a fractured fibula the worst possible scenario.
Reynolds emerged on the Rabbitohs bench during the second half at ANZ Stadium on crutches.
For Keary, the concussion is a cruel blow after being heralded as arguably the form player of the league.
The back of his head bounced on the turf at McDonald Jones Stadium on Friday night after being bullocked by Daniel Saifiti in the eighth minute.
He momentarily lay prone before staggering from the field.
His latest concussion comes five weeks after also being forced to miss the club's traditional Anzac Day clash due to a head knock.
Roosters coach Trent Robinson described Keary's health as "average" after the game, and said the 27-year-old would be unlikely to train until Tuesday.
"They can't do contact until day four, I think it is. They've got to make sure that they don't have headaches (the next day)," Robinson said.
