Ibrahimovic took to Instagram to announce his intentions after the death toll in the country surpassed 2,500.
"Italy has always given me so much and, in this dramatic moment, I want to give back even more to this country that I love," the 38-year-old said.
"I decided, together with the people who are working with me, to create a fundraiser for Humanitas hospitals and to use my communication power to spread the message wider.
"It's a serious issue and we need a concrete help that's not just about a video.
"I count on the generosity of my colleagues, of all professional athletes and of those who want to make a small or large donation according to their possibilities, to kick the virus away.
"Together we can really help hospitals and doctors and nurses who selflessly work every day to save our lives.
"Because today we are the ones cheering for them!
"Let's together kick the coronavirus away and win this match! And remember: if the virus don't go to Zlatan, Zlatan goes to the virus!"
Italy has been the worst affected country as a result of the pandemic's presence, with more than 30,000 recorded cases in the country.
Ibrahimovic, back in Milan following a brief but memorable stint in the MLS, has joined Paul Pogba, Sadio Mane and Son Heung-min on a growing list of high-profile footballers to have made the effort to aid relief.
